HPV testing
Gene | Products | Tumors |
---|---|---|
ABL1 | Tyrosine kinase | CML |
BCL2 | Anti-apoptotics | Follicular lymphoma |
BRAF | Serine/Threonine kinase (STK) | Melanoma |
EGFR [HER1] [ERBB1] | Tyrosine kinase | Non-small cell lung cancer (NSCLC) Colorectal cancer |
NEU [HER2] [ERBB2] | Tyrosine kinase | Breast cancer |
C-KIT | Tyrosine kinase | Gastrointestinal stromal tumor (GIST) |
C-MYC | Transcription factor | Burkitt lymphoma |
L-MYC | Transcription factor | Small cell lung cancer (SCLC) |
N-MYC | Transcription factor | Neuroblastoma |
KRAS | GTPase | Lung cancer Colorectal cancer Pancreatic cancer |
RET | Tyrosine kinase | MEN 2A & 2B |
Gene | Products | Tumors |
---|---|---|
APC | - | Familial adenomatous polyposis (FAP) |
ATM | DNA repair | Ataxia telangiectasia |
BRCA | DNA repair | Breast cancer Ovarian cancer |
ERCC | DNA repair | Xeroderma pigmentosum |
FANC | DNA repair | Fanconi anemia |
MEN1 | Menin | MEN 1 |
MLH1 MSH2 | DNA repair | Lynch syndrome |
NF1 NF2 | RAS activators | Neurofibromatosis (NF) type 1 Neurofibromatosis (NF) type 2 |
P16 | CDK inhibitors | Melanoma |
P53 | Transcription factor for P21 | Li-Fraumeni syndrome |
PTEN | - | Breast cancer Prostate cancer Endometrial cancer |
RB | E2F inhibitors | Retinoblastoma Osteosarcoma |
TSC1 TSC2 | Hamartin Tuberlin | Tuberous sclerosis |
VHL | HIF inhibitors | Von Hippel-Lindau (VHL) disease |
WT1 WT2 | - | Wilms tumor |
Marker | Tumors |
---|---|
5-HIAA | Carcinoid tumors |
AFP | Hepatocellular carcinoma Germ cell tumors (GCT) |
ALP | Bone metastasis Liver metastasis Seminoma |
CA 125 | Ovarian cancer |
CA 15-3 CA 27-29 | Breast cancer |
CA 19-9 | Pancreatic adenocarcinoma |
CEA | Colorectal cancer Pancreatic adenocarcinoma |
Calcitonin | Medullary thyroid carcinoma |
Chromogranin Synaptophysin NSE | Neuroendocrine tumors (NET) |
Desmin | Myoma Myosarcoma |
GFAP | Glioma Glioblastoma Schwannoma |
hCG | Hydatidiform moles Germ cell tumors (GCT) |
HVA VMA | Pheochromocytoma |
Keratin | Carcinoma |
Neurofilament | Neuroblastoma |
PSA | Prostate cancer |
S-100 | Neural crest tumors Histiocytosis |
TRAP | Hairy cell leukemia |
Vimentin | Sarcoma |
Syndrome | Cancer |
---|---|
ACTH | Small cell carcinoma |
hCG | Large cell carcinoma |
Lambert-Eaton myasthenic syndrome | Small cell carcinoma |
Myasthenia gravis | Thymoma |
PTHrP | Squamous cell carcinoma Renal cell carcinoma |
SIADH | Small cell carcinoma |
Acanthosis nigricans | Visceral malignancy |
Erythema nodosum | Non-Hodgkins lymphoma |
Migratory thrombophlebitis Trousseau syndrome | Pancreatic adenocarcinoma |
Necrolytic migratory erythema | Glucagonoma |
Seborrheic keratosis Leser-Trélat sign | Visceral malignancy |
Dermatomyositis | Malignancy |
Virus | Cancers |
---|---|
HBV HCV | Liver cancer |
HPV | Cervical cancer Oropharyngeal cancer |
EBV | Burkitt lymphoma CNS lymphoma Nasopharyngeal cancer Lymphoproliferative disease |
HHV8 | Kaposi sarcoma |
HTLV | T-cell leukemia |
Imaging | Indications |
---|---|
Bone scan | Prostate cancer Small cell lung cancer Hodgkin lymphoma |
PET | Breast cancer Multiple myeloma Non-small cell lung cancer Non-Hodgkin lymphoma |
Mechanism | Medication | Indications |
---|---|---|
BRAF inhibitors | Vemurafenib | Melanoma |
C-KIT inhibitors | Imatinib | Gastrointestinal stromal tumor (GIST) |
EGFR inhibitors | Cetuximab | Colorectal cancer |
Gefitinib Erlotinib | Non-small cell lung cancer (NSCLC) | |
HER2 inhibitors | Trastuzumab | Breast cancer |
VEGF inhibitors | Bevacizumab | Solid tumors |
VEGFR inhibitors | Sunitinib Sorafenib | Cancer |
Regorafenib | Colorectal cancer (CRC) |
Mechanism | Medication |
---|---|
TLR7 activators | Imiquimod |
CTLA-4 inhibitors | Ipilimumab |
PD-1 inhibitors | Nivolumab Pembrolizumab |
PD-L1 inhibitors | Atezolizumab Avelumab Durvalumab |
Side Effect | Drugs |
---|---|
Immunosuppression | - |
Marrow toxicity | - |
Nephrotoxicity | Platinums |
Ototoxicity | Platinums |
Neurotoxicity | Nitrosoureas Platinums Vincas Taxanes |
Cardiotoxicity | Anthracyclines Trastuzumab |
Pulmonary fibrosis | Bleomycin Busulfan |
Hemorrhagic cystitis | Cyclophosphamide |
Mnemonic | Cancer |
---|---|
O | Oral |
N | Nasopharyngeal |
L | Laryngeal |
Y | Lymphoma |
Cure | Cervical |
Possible | Prostate |