Pharmacology

Cytochrome P-450 (CYP450) Interactions

Inducers {CGR-MASP}

  • Carbamazepine
  • Griseofulvin
  • Rifampin
  • Modafinil
  • Alcohol :: chronic
  • St. John wort
  • Phenytoin
  • Phenobarbital

Substrates {ATWO}

  • Anticonvulsants
  • Theophylline
  • Warfarin
  • Oral contraceptive pills (OCPs)

Inhibitors {CIGAR-MASQ}

  • Cimetidine
  • -Conazoles
  • Isoniazid
  • Grapefruit
  • Amiodarone
  • Ritonavir
  • Macrolides
  • Metronidazole
  • Alcohol :: acute
  • Sulfonamides
  • Quinolone
  • Quinidine
  • Valproate
  • Omeprazole

Sulfa Drugs {P-FACTSSS}

  • Probenecid
  • Furosemide
  • Acetazolamide
  • Celecoxib
  • Thiazides
  • Sulfonamides
  • Sulfonylureas
  • Sulfasalazine

Medications Targeting Ion Channels

Mechanism Medication Indications
Na channel activators Batrachotoxin
Ciguatoxin
-
Na channel blockers Quinidine
Procainamide
Disopyramide
Arrhythmia
  Lidocaine
Mexiletine
Arrhythmia
  Flecainide
Propafenone
Arrhythmia
  -Caines Anesthesia
  Amiloride
Triamterene
Diuretics
  Phenytoin Seizure
  Valproate Seizure
Bipolar disorder
Migraine
  Carbamazepine Seizure
Bipolar disorder
Trigeminal neuralgia
  Lamotrigine Seizure
Bipolar disorder
  Topiramate Seizure
Migraine
Idiopathic intracranial hypertension (IIH)
  Saxitoxin
Tetrodotoxin
-
K channel activators Diazoxide Vasodilation
Insulinoma
  Minoxidil Vasodilation
Alopecia
K channel blockers Amiodarone
Ibutilide
Dofetilide
Sotalol
Arrhythmia
  Sulfonylureas DM type 2
  Aminopyridine -
Ca channel activators - -
Ca channel blockers Verapamil
Diltiazem
Arrhythmia
Cluster headache
  -Dipines Vasodilation
Diffuse esophageal spasm (DES)
  Dantrolene Malignant hyperthermia
NMS
  Ethosuximide Seizure
  Gabapentin
Pregabalin
Seizure
Neuropathic pain
Restless legs syndrome (RLS)
Na-K pump blockers Digitalis Arrhythmia
Inotrope
  Ouabain -
H-K pump blockers
[Proton pump inhibitors (PPI)]
-Prazoles PUD
Na-K-2Cl sympoter blockers Loop diuretics:
Furosemide
Bumetanide
Torsemide
Diuretics
Na-Cl sympoter blockers Thiazides:
Hydrochlorothiazide
Chlorthalidone
Diuretics
Na-I sympoter blockers Thiocyanate
Perchlorate
Iodine
Hyperthyroidism

Medications Targeting Cholinergic Neurons

Mechanism Medication Indications
Choline uptake inhibitors Hemicholinium -
Vesicular transporter inhibitors Vesamicol -
ACh release inhibitors Botulinum toxin Muscle relaxant
ACh release inducers - -
ACh esterase inhibitors Edrophonium Myasthenia diagnosis
  Pyridostigmine Myasthenia
  Neostigmine Muscle relaxant reversal
  Physostigmine Atropine antidote
  Rivastigmine
Galantamine
Donepezil
Alzheimer disease
  Organophosphates
Sarin
Glaucoma
ACh reuptake inhibitors -  

Medications Targeting Adrenergic Neurons

Mechanism Medication Indications
Tyrosine uptake inhibitors - -
VMAT2 inhibitors Reserpine
Tetrabenazine
Valbenazine
Huntington disease
Tourette syndrome
Tardive dyskinesia
NE release inhibitors Bretylium Arrhythmia
  Guanethidine Hypertension
NE release inducers Ephedrine Decongestant
  Tyramine -
MAO inhibitors Tranylcypromine
Phenelzine
Isocarboxazid
Selegiline
Depression
Anxiety
Parkinson disease
COMT inhibitors -Capones Parkinson disease
Reuptake inhibitors NRIs
DRIs
NDRIs
TCAs
SSRIs
SNRIs
-

Medications Targeting GABAergic Neurons

Mechanism Medication Indications
Vesicular transporter inhibitors - -
GABA release inhibitors Tetanus toxin -
GABA release inducers - -
GABA transaminase inhibitors Vigabatrin Seizure
GABA reuptake inhibitors Tiagabine Seizure

Medications Targeting Neurotransmitter Reuptake

Mechanism Medication Indications
NRIs Atomoxetine ADHD
DRIs Modafinil Narcolepsy
NDRIs Methylphenidate ADHD
Narcolepsy
  Cocaine
Amphetamine
MDMA [Ecstasy]
-
  Bupropion Depression
Smoking cessation
TCAs -Triptylines
-Pramines
Depression
Anxiety
OCD
Cataplexy
Neuropathic pain
Migraine
Tension headache
Diffuse esophageal spasm (DES)
Enuresis
SSRIs Fluoxetine
Paroxetine
Sertraline
Citalopram
Depression
Anxiety
OCD
Cataplexy
Premenstrual syndrome (PMS)
Menopause
SNRIs Duloxetine
Venlafaxine
Desvenlafaxine
Depression
Anxiety
OCD
Cataplexy
Neuropathic pain
Menopause
GRIs Tiagabine Seizure
  • Norepinephrine reuptake inhibitors (NRIs)
  • Dopamine reuptake inhibitors (DRIs)
  • Norepinephrine-dopamine reuptake inhibitors (NDRIs)
  • Selective serotonin reuptake inhibitors (SSRIs)
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs)
  • GABA reuptake inhibitors (GRIs)

Cholinergic Agonists

Mechanism Medication Indications
M agonists Bethanechol Urinary retention
  Methacholine Asthma diagnosis
  Carbachol Glaucoma
  Pilocarpine Glaucoma
Xerophthalmia
Xerostomia
NN agonists Nicotine Stimulant
  Varenicline Smoking cessation
NM agonists Succinylcholine Muscle relaxant

Cholinergic Antagonists

Mechanism Medication Indications
M antagonists Atropine
Tropicamide
Mydriasis
Cycloplegia
  Benztropine Parkinson disease
Extrapyramidal symptoms (EPS)
  Ipratropium
Tiotropium
Asthma
  Scopolamine Emesis
  Oxybutynin
Tolterodine
Urinary incontinence
  Glycopyrrolate -
  Antipsychotics -
  Antidepressants :: TCAs -
  1° Antihistamines -
NN antagonists Hexamethonium -
  Mecamylamine -
NM antagonists Atracurium
Rocuronium
Muscle relaxant

Adrenergic Agonists

Mechanism Medication Indications
α1 agonists Phenylephrine Hypotension
Decongestant
  Midodrine Hypotension
α2 agonists Methyldopa Hypertension
  Clonidine
Guanfacine
Hypertension
Tourette syndrome
Opioid withdrawal
  Brimonidine Glaucoma
  Tizanidine Muscle relaxant
β1 agonists Dobutamine Inotrope
β2 agonists Albuterol Asthma :: acute
  Salmeterol
Formoterol
Asthma :: chronic
  Terbutaline
Ritodrine
Tocolysis
β agonists Isoproterenol -
αβ agonists Norepinephrine Hypotension
  Epinephrine Hypotension
Asthma

Adrenergic Antagonists

Mechanism Medication Indications
α1 antagonists Tamsulosin
Terazosin
Doxazosin
Prazosin
BPH
Hypertension
Pheochromocytoma
α2 antagonists Mirtazapine Depression
α antagonists Phentolamine
Phenoxybenzamine
Pheochromocytoma
  Antipsychotics -
  Antidepressants :: TCAs -
  1° Antihistamines -
β1 antagonists Acebutolol Partial agonists
  Atenolol Arrhythmia
  Bisoprolol Heart failure (HF)
  Esmolol Arrhythmia
  Metoprolol Arrhythmia
Heart failure (HF)
β2 antagonists - -
β antagonists Nadolol -
  Pindolol Partial agonists
  Propranolol Arrhythmia
Esophageal varices
Hyperthyroidism
Anxiety
Akathisia
Essential tremor
Migraine
Performance anxiety
  Sotalol Arrhythmia
  Timolol Arrhythmia
Glaucoma
αβ antagonists Carvedilol Arrhythmia
Heart failure (HF)
  Labetalol Hypertension

Medications Targeting Dopamine Receptor

Mechanism Medication Indications
D agonists Dopamine Inotrope
D1 agonists Fenoldopam Hypertension
D2 agonists Bromocriptine Parkinson disease
Prolactinoma
NMS
  Cabergoline Parkinson disease
Prolactinoma
  Pramipexole Parkinson disease
Restless legs syndrome (RLS)
  Ropinirole Parkinson disease
Restless legs syndrome (RLS)
D2 antagonists Metoclopramide
Prochlorperazine
Domperidone
Droperidol
Emesis
  Antipsychotics Psychosis
Huntington disease
Tourette syndrome
Bipolar disorder

Medications Targeting Serotonin Receptor

Mechanism Medication Indications
5-HT1 agonists Buspirone Anxiety
  -Triptans Cluster headache
Migraine
  Ergotamine Migraine
5-HT2 antagonists 2° Antipsychotics Psychosis
  Cyproheptadine Carcinoid syndrome
Serotonin syndrome
5-HT3 antagonists -Setrons Emesis
5-HT4 agonists Cisapride
Mosapride
Constipation
5-HT modulators Trazodone Depression
Insomnia

Medications Targeting Histamine Receptor

Mechanism Medication Indications
H1 antagonists 1° Antihistamines:
Chlorpheniramine
Diphenhydramine
Meclizine
Promethazine
Allergy
Emesis
  2° Antihistamines:
Cetirizine
Fexofenadine
Loratadine
Allergy
  Antipsychotics -
  Antidepressants :: TCAs -
H2 antagonists Cimetidine
Ranitidine
Famotidine
Nizatidine
PUD

Medications Targeting Glutamate Receptor

Mechanism Medication Indications
NMDA agonists - -
NMDA antagonists Memantine Alzheimer disease
  Amantadine Parkinson disease
NMS
  Riluzole Amyotrophic lateral sclerosis (ALS)
  Dextromethorphan Coughing
  Ketamine
Phencyclidine (PCP)
Anesthesia
Hallucinogen

Medications Targeting GABA Receptor

Mechanism Medication Indications
GABAA agonists Barbiturates Anesthesia
Seizure
Essential tremor
  Benzodiazepines Anesthesia
Seizure
Insomnia
NMS
Catatonia
Akathisia
Bulimia nervosa
  Propofol Anesthesia
  Etomidate Anesthesia
  Zolpidem
Zaleplon
Eszopiclone
Insomnia
  Alcohol -
GABAB agonists Baclofen Muscle relaxant
  γ-Hydroxybutyrate (GHB) -
GABAA antagonists Flumazenil Benzodiazepine antidote
GABAB antagonists - -

Medications Targeting Opioid Receptor

Mechanism Medication Indications
μ-opioid agonists Codeine Analgesia
  Tramadol Analgesia
  Morphine Analgesia
Venoodilation
  Meperidine Analgesia
  Oxycodone Analgesia
  Fentanyl Analgesia
  Loperamide Diarrhea
  Diphenoxylate Diarrhea
  Methadone Opioid cessation
  Buprenorphine Opioid cessation
  Heroin -
μ-opioid antagonists Naloxone Opioid antidote
  Naltrexone Alcohol cessation

Medications Targeting Growth Hormone

Mechanism Medication Indications
Somatostatin agonists Octreotide Acromegaly
Insulinoma
Esophageal varices
  Lanreotide Acromegaly
GH antagonists Pegvisomant Acromegaly
IGF-1 agonists Mecasermin Dwarfism

Medications Targeting Thyroid Hormone

Mechanism Medication Indications
Thyroid peroxidase inhibitors Propylthiouracil
Methimazole
Iodine [Lugol] solution
Hyperthyroidism
Deiodinase inhibitors Propylthiouracil
Propranolol
Corticosteroids
Hyperthyroidism
TH agonists Levothyroxine
Triiodothyronine
Hypothyroidism

Medications Targeting Sex Hormones

Mechanism Medication Indications
GnRH agonists Leuprolide
Goserelin
Nafarelin
Infertility
GnRH antagonists GnRH agonists Infertility
Precocious puberty
Endometriosis
Breast cancer
Prostate cancer
  Degarelix Prostate cancer
  Cetrorelix
Ganirelix
Infertility
LH agonists Lutropin
Menotropin
Infertility
FSH agonists Follitropin
Menotropin
Infertility
hCG agonists Choriogonadotropin Infertility
Estrogen agonists Diethylstilbestrol (DES)
Mestranol
HRT
Contraception
Estrogen modulators Clomiphene Anovulation
  Tamoxifen Breast cancer
  Raloxifene Breast cancer
Osteoporosis
Progesterone agonists Progestin
Medroxyprogesterone
Norethindrone
Desogestrel
HRT
Contraception
Progesterone antagonists Mifepristone
Ulipristal
Abortion
Aromatase inhibitors Anastrozole
Letrozole
Exemestane
Breast cancer
Anovulation
Androgen agonists Methyltestosterone HRT
  Danazol Endometriosis
Androgen antagonists Flutamide
Bicalutamide
Prostate cancer
5α-Reductase inhibitors Finasteride BPH
Alopecia
Androgen synthesis inhibitors Ketoconazole
Spironolactone
PCOS

Medications Targeting Mineralocorticoid

Mechanism Medication Indications
Renin inhibitors Aliskiren Hypertension
ACE inhibitors (ACEI) -Prils Hypertension
Heart failure (HF)
AT1 antagonists (ARB) -Sartans Hypertension
Heart failure (HF)
Mineralocorticoid receptor antagonists (MRA) Spironolactone
Eplerenone
Diuretics

Medications Targeting Vasopressin Receptor

Mechanism Medication Indications
V2 agonists Desmopressin DI
Enuresis
Hemophilia A
Von Willebrand disease (VWD)
Uremic bleeding
V2 antagonists -Vaptans SIADH

Medications Targeting Oxytocin Receptor

Mechanism Medication Indications
Oxytocin agonists Carbetocin Labor
Oxytocin antagonists Atosiban Tocolysis

Medications Targeting Autacoid Receptor

Mechanism Medication Indications
PGE1 agonists Misoprostol Labor
Abortion
PUD
  Alprostadil Impotence
PDA maintenance
PGF2 agonists Latanoprost Glaucoma
PGI2 agonists Epoprostenol Pulmonary hypertension
TXA2 antagonists - -
LTD4 antagonists Montelukast Asthma
  Zafirlukast Asthma
ETA antagonists Bosentan Pulmonary hypertension

Medications Targeting Enzymes

Mechanism Medication Indications
PDE inhibitors Inamrinone
Milrinone
Inotrope
  Methylxanthines:
Theophylline
Caffeine
Asthma
  Sildenafil
Vardenafil
Impotence
Pulmonary hypertension
  Dipyridamole
Cilostazol
Antiplatelet
Vasodilation
COX inhibitors NSAIDs:
Aspirin
Ibuprofen
Naproxen
Diclofenac
Ketorolac
Meloxicam
Indomethacin
Antipyresis
Analgesia
Inflammation
Antiplatelet
Tocolysis
PDA closure
  Acetaminophen Antipyresis
Analgesia
  Sulfasalazine
Mesalazine
Inflammatory Bowel Disease (IBD)
Rheumatoid Arthritis
COX-2 inhibitors Celecoxib Arthritis
LOX inhibitors Zileuton Asthma
ADH inhibitors Ethanol Methanol antidote
  Fomepizole Methanol antidote
ALDH inhibitors Disulfiram Alcohol cessation
Xanthine oxidase inhibitors Allopurinol
Febuxostat
Gout
Nitrates Nitroprusside
Hydralazine
Vasodilation
  Nitroglycerin
Isosorbide
Venoodilation
Diffuse esophageal spasm (DES)
Esophageal varices

Antimicrobials and Antineoplastics

Mechanism Target Species
Cell wall inhibitors Peptidoglycan Bacterium
  Mycolate Mycobacterium
  Arabinogalactan Mycobacterium
  β-Glucan Fungus
Cell membrane inhibitors Phosphatidylglycerol Bacterium
  Ergosterol Fungus
  Cholesterol Human
Nucleotide inhibitors Folate
Purine
Pyrimidine
-
DNA inhibitors DNA -
RNA inhibitors RNA -
Microtubule inhibitors Microtubule -
Protein inhibitors Ribosome -

Cell Wall Inhibitors

Mechanism Medication Species
↓ Peptidoglycan crosslinking Penicillin
Cephalosporin
Carbapenem
Monobactam
Bacterium
↓ Peptidoglycan synthase Glycopeptide Bacterium
↓ Enoyl-ACP reductase Isoniazid Mycobacterium
↓ Arabinosyl transferase Ethambutol Mycobacterium
↓ β-Glucan synthase Echinocandins [-Fungins]:
Anidulafungin
Capsofungin
Micafungin
Fungus

Cell Membrane Inhibitors

Mechanism Medication Species
↑ Phosphatidylglycerol damage Daptomycin
Polymyxins
Bacterium
↑ Ergosterol damage Amphotericin B
Nystatin
Fungus
↓ Squalene epoxidase Terbinafine Fungus
↓ Demethylase -Conazoles Fungus

Nucleotide Inhibitors

Mechanism Medication Species
↓ Dihydropteroate synthase Sulfonamides:
Sulfamethoxazole
Sulfisoxazole
Sulfadiazine
Sulfapyridine
Bacterium
Protozoa
↓ Dihydrofolate reductase Trimethoprim Bacterium
  Pyrimethamine Protozoa
  Methotrexate Human
↓ IMP dehydrogenase Ribavirin Virus
  Mycophenolate Human
↓ PRPP amidotransferase Azathioprine Human
  6-Mercaptopurine (6-MP) Human
  6-Thioguanine (6-TG) Human
↓ Dihydroorotate dehydrogenase Leflunomide Human
↓ Thymidylate synthase Flucytosine Fungus
  5-Fluorouracil (5-FU) Human
↓ Ribonucleotide reductase Hydroxyurea Human

DNA Inhibitors

Mechanism Medication Species
↓ Reverse transcriptase NRTI
NNRTI
Virus
↓ DNA polymerase Acyclovir
Famciclovir
Ganciclovir
Cidofovir
Foscarnet
Virus
  Cladribine
Cytarabine
Gemcitabine
Human
↓ Topoisomerase Fluoroquinolone Bacterium
↓ Topoisomerase 1 Camptothecins [-Tecans] Human
↓ Topoisomerase 2 Podophyllotoxins [-Posides] Human
↓ DNA methyltransferase Azacitidine Human
  Decitabine Human
↑ DNA intercalation Metronidazole Bacterium
  Benznidazole Parasite
  Streptomycin Mycobacterium
  Anthracyclines [-Rubicins]:
Doxorubicin
Daunorubicin
Human
  Bleomycin Human
  Dactinomycin Human
↑ DNA crosslinking Busulfan Human
  Cyclophosphamide Human
  Nitrosoureas Human
  Platinums [-Platins] Human

RNA Inhibitors

Mechanism Medication Species
↓ RNA polymerase Rifampin Mycobacterium
  α-Amanitin Human

Microtubule Inhibitors

Mechanism Medication Species
↓ Microtubule assembly Benzimidazole Parasite
  Griseofulvin Fungus
  Colchicine Human
  Vinca alkaloids:
Vinblastine
Vincristine
Human
↑ Microtubule disassembly Taxanes [-Taxels] Human

Protein Inhibitors

Mechanism Medication Species
↓ Protein synthesis IFN-α Virus
↓ 30S ribosome :: initiation complex Aminoglycosides Bacterium
↓ 50S ribosome :: initiation complex Linezolid Bacterium
↓ 30S ribosome :: tRNA binding Tetracycline Bacterium
↓ 50S ribosome :: peptidyl transferase Chloramphenicol Bacterium
↓ 50S ribosome :: mRNA translocation Macrolide Bacterium
  Clindamycin Bacterium
↓ Elongation factor (EF-2) Diphtheria toxin Human
  Exotoxin A Human
↓ 60S ribosome Shiga toxin Human
  Shiga-like toxin Human

Miscellaneous Intracellular Targets

Mechanism Medication Indications
NF-κB inhibitors Corticosteroids Immunosuppression
Calcineurin inhibitors Cyclosporine
Tacrolimus
Immunosuppression
mTOR inhibitors Sirolimus
Everolimus
Immunosuppression

Medications with Miscellaneous Targets

Mechanism Medication Indications
ABL1 inhibitors Imatinib Chronic myelogenous leukemia (CML)
BRAF inhibitors Vemurafenib Melanoma
C5 inhibitors Eculizumab Hemolytic uremic syndrome (HUS)
Paroxysmal nocturnal hemoglobinuria (PNH)
Neuromyelitis optica
CD20 inhibitors Rituximab Immunosuppression
Non-Hodgkin lymphoma
  Ocrelizumab Multiple sclerosis
CD52 inhibitors Alemtuzumab Chronic lymphocytic leukemia (CLL)
Multiple sclerosis
C-KIT inhibitors Imatinib Gastrointestinal stromal tumor (GIST)
EGFR inhibitors Cetuximab Colorectal cancer
  Gefitinib
Erlotinib
Non-small cell lung cancer (NSCLC)
F protein inhibitors Palivizumab RSV
Gp2b/3a inhibitors Abciximab Antiplatelet
HER2 inhibitors Trastuzumab Breast cancer
IgE inhibitors Omalizumab Asthma
IL-2R inhibitors Basiliximab
Daclizumab
Immunosuppression
IL-6R inhibitors Tocilizumab Immunosuppression
JAK2 inhibitors Ruxolitinib Polycythemia vera (PCV)
Essential thrombocytosis
Myelofibrosis
RANKL inhibitors Denosumab Osteoporosis
TNF-α inhibitors Etanercept
Infliximab
Adalimumab
Immunosuppression
VEGF inhibitors Bevacizumab Solid tumors
Diabetic retinopathy
Age-related macular degeneration (AMD)
  Ranibizumab Diabetic retinopathy
Age-related macular degeneration (AMD)
VEGFR inhibitors Sunitinib
Sorafenib
Cancer
  Regorafenib Colorectal cancer (CRC)
  Pegaptanib Age-related macular degeneration (AMD)
α4-integrin inhibitors Natalizumab Multiple sclerosis
Crohn disease

Medications Causing QT Prolongation {ABCDE}

  • Antiarrhythmics :: class 1A & 3
  • Antibiotics :: Macrolide & Fluoroquinolone
  • Antipsychotics & Hypocalcemia
  • Antidepressants :: TCAs
  • Antiemetics :: Ondansetron

Medications Causing Agranulocytosis

Mnemonic Medication
Cannot Carbamazepine
Properly Propylthiouracil
Make Methimazole
Circulating Clozapine
Granulo- Ganciclovir
Cytes Colchicine

Medications Causing Aplastic Anemia

Mnemonic Medication
Cannot Carbamazepine
Properly Propylthiouracil
Make Methimazole
New NSAIDs
Blood Benzene
Cells Chloramphenicol

Medications Causing Megaloblastic Anemia

  • Methotrexate
  • Phenytoin
  • Sulfonamides
  • Trimethoprim

Medications Causing Hemolysis in G6PD Deficiency {IS-D-PAIN}

  • Isoniazid
  • Sulfa drugs
  • Dapsone
  • Primaquine
  • Aspirin
  • Ibuprofen
  • Nitrofurantoin

Medications Causing Osteoporosis

  • Corticosteroids
  • Heparin

Medications Causing Photosensitivity {FAST}

  • Flucytosine
  • Amiodarone
  • Sulfonamides
  • Tetracycline

Medications Causing SLE-like Syndrome {HIPPIES}

  • Hydralazine
  • Isoniazid
  • Procainamide
  • Primaquine
  • Isoniazid
  • Etanercept
  • Sulfa drugs

Medications Causing Seizures

  • Bupropion
  • Enflurane
  • Imipenem
  • Isoniazid

Medications Causing Parkinson-like Syndrome {RAM}

  • Reserpine
  • Antipsychotics
  • Metoclopramide

Medications Causing Disulfiram-like Reaction

  • Griseofulvin
  • Metronidazole
  • Procarbazine
  • Sulfonylureas

Medications Causing Nephrotoxicity & Ototoxicity

  • Aminoglycosides
  • Cisplatin
  • Loop diuretics
  • Vancomycin

Medications Causing Gynecomastia

Mnemonic Medication
Some Spironolactone
Drugs Digitalis
Create Cimetidine
Awesome Alcohol
Knockers Ketoconazole

Medications Causing Nephrogenic DI

  • Lithium
  • Demeclocycline

Medications Causing SIADH

Mnemonic Medication
Cannot Carbamazepine
Concentrate Cyclophosphamide
Sodium SSRIs

Side Effects of Lithium

  • Hyperreflexia
  • Hypothyroidism
  • Nephrogenic diabetes insipidus
  • Ebstein anomaly

Medications Following Zero-order Elimination {APE}

  • Aspirin
  • Phenytoin
  • Ethanol